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Original Article

Progress in Orthodontics 3, 2002;12-16
Official Journal of SIDO(Societa Italiana di Ortodonzia)

 Localization of nitric oxide synthase in the periodontal
tissues of orthodontically moved and stationary teeth

Joseph M. Brogan, Kook Jin Kang, Eiki Koyama, Orhan C. Tuncay


There is ample evidence that the inflammatory response and vascular supply of the periodontal tissues is crucial to mediation the effects of applied force.
The connection between mechanical forces and vascular activity, however, is not well defined.
Nitric oxide(NO), a molecule only recently recognized as a chemical messenger within biologic systems, has been shown to be central to these processes in many parts of the body, but not during tooth movenet.
Therefore, the aim of this investigation was to identify the sites of endothelial nitric oxide synthase(eNOS) and inducible nitric oxide synthase(iNOS) activity in the periodontal tissues of moved and stationary teeth immunohistochemically.
Our data show that the presence of less eNOS and iNOS. There is an increased amount of eNOS produced after rat molar tooth movement in blood vessel walls.
Similarly, increased amounts of iNOS produced after rat molar tooth movement in the periodontal ligament and connective tissue between roots of moved teeth as well as around blood vessels could be seen.
The presence of eNOS and iNOS was consistently seen in the odontoblast layer of pulp chambers of moved and stationary teeth. Our results indicate a possible role of NO in periodontal remodeling during tooth movement.

Key words : immunohistochemistry, nitric oxide, orthodontic tooth movement, rat periodontal tissues

Authors' affiliations:
Joseph M. Brogan, 5912 Ridge Ave.,Philadelphia, PA, USA
Kook Jin Kang, School of Dentistry, Temple University, Philadelphia, PA, USA
Eiki Koyama, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
Orhan C. Tuncay, School of Dentistry, Temple University, Philadelphia, PA, USA

Correspondence to:
Dr Orhan C. Tuncay Department of Orthodontics 3223 N. Broad Street Temple University Philadelphia, PA 19 140-5096, USA
Tel: +1 215 707-7733
Fax: +1 215 707-7228
E-mail: otuncay@dental.temple.edu


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